ORF8 of SARS-CoV-2 as a promising target protein for COVID 19 treatment; Open Reading Frame 8 (ORF 8 as a unique protein is known to play key roles in host immune regulation and immune evasion Most striking of them are interaction with Major Histocompatibility Complex 1 (MHC 1), Interleukin 6 production and, the antagonistic effect …
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Immune response; IL-1 family of cytokines
IL-1 family of cytokines are key proteins in the regulation of the immune response. IL-1 Receptor Type I (IL-1RI) is their major receptor for triggering the immune responses upon stress and injury. Receptor Type II is an orphan receptor that is homologous to IL-1RI and binds to similar cytokines. I use molecular modelling to study …
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