Promoted “twist-turn” motions in the glycosylated EGFR-ed dimer is mediated by interactions of counterpart glycans in the dimeric interface.
EGFR-ed extracellular domain is shown with grey surface. The transmembrane and intracellular domains are shown with pink and magenta surface. Cell membrane is shown as lines. dimeric interfaces and module2 module8 of subdomains II from the two monomers are shown with marine and green surface respectively. Overlaid structures of glycans attached to Asn172, Asn337 and 579 of monomer1 and monomer2 from the simulations are shown with yellow and orange sticks. Dashed line shows the axis of the dimeric conformation. Twist and turn motions are schematically presented by one and two sided arrows.