IL-1 family of cytokines are key proteins in the regulation of the immune response. IL-1 Receptor Type I (IL-1RI) is their major receptor for triggering the immune responses upon stress and injury. Receptor Type II is an orphan receptor that is homologous to IL-1RI and binds to similar cytokines. I use molecular modelling to study the interplay between these two receptors in different pathological conditions.
